Nov 24, 2025 8:15 PM EST

Week 12

Carolina

7-4

San Francisco

-7 (-110)o49 (-110)

ESPN, 206

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Carolina Panthers vs San Francisco 49ers Odds

Updated:Nov 19, 2025 1:33 AM EST

The Monday night football clash on November 24, 2025, between the Carolina Panthers and San Francisco 49ers at Levi's Stadium in Santa Clara, CA, promises an exciting NFL showdown. Fans and bettors alike will be tuning in on ESPN to catch all the action.

Currently, the San Francisco 49ers are favored with a point spread of -7 -110, while the Carolina Panthers are the underdogs at +7 -109. These betting lines have shifted slightly from the opening odds, indicating growing confidence in the 49ers' ability to secure a solid win at home. The total points line is set at 48.5, with the over priced at -114 and the under at -107, providing interesting options for totals bettors.

Understanding these odds and betting lines is crucial for making informed wagers. The 49ers' strong home record at Levi's Stadium in Santa Clara, CA, combined with their favored status, suggests they have the edge, but the Panthers' potential to cover the spread keeps the game intriguing. Bettors looking to capitalize on these insights can explore more detailed NFL odds on our league odds page and enhance their betting strategy by starting an OddsTrader Turbo subscription. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

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Personalize your notifications and get updates on the teams, players or events you care about most. THU 11/208:15 PM Buffalo 7-3 28% -5½ -122FanDuel
Houston 5-5 72% +6 -109Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM Pittsburgh 6-4 44% +3 -120BetRivers
Chicago 7-3 56% -2½ -114Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM N.Y. Jets 2-8 84% +14 -115Bet365
Baltimore 5-5 16% -13½ -108Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM N.Y. Giants 2-9 95% +11 -114BetRivers
Detroit 6-4 5% -10½ -102FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM New England 9-2 28% -7 -115Caesars
Cincinnati 3-7 72% +7½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM Seattle 7-3 16% -12½ -110Bet365
Tennessee 1-9 84% +13½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM Minnesota 4-6 83% +6½ -110Caesars
Green Bay 6-3-1 17% -6½ -109Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM Indianapolis 8-2 73% +3½ -114Caesars
Kansas City 5-5 27% -3½ -102BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/234:05 PM Jacksonville 6-4 43% -2½ -112FanDuel
Arizona 3-7 57% +3 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/234:05 PM Cleveland 2-8 38% +4 -109BetRivers
Las Vegas 2-8 62% -3½ -118FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/234:25 PM Atlanta 3-7 33% +1½ -108Caesars
New Orleans 2-8 67% +1 -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/234:25 PM Philadelphia 8-2 46% -3 -113Caesars
Dallas 4-5-1 54% +3½ -115BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/238:20 PM Tampa Bay 6-4 64% +6½ -102FanDuel
L.A. Rams 8-2 36% -6½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. MON 11/248:15 PM Carolina 6-5 91% +7 -109Caesars
San Francisco 7-4 9% -6½ -115Bet365

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