49ers vs Buccaneers Odds - NFL Showdown

The upcoming clash between the San Francisco 49ers and Tampa Bay Buccaneers on October 12, 2025, at Raymond James Stadium in Tampa, FL, promises an exciting showdown in the NFL. This Sunday football game will be broadcasted on CBS, offering an electrifying matchup for fans and bettors alike. The 49ers, entering as the underdogs with a point spread of +3½ -111, aim to challenge the Buccaneers, who hold a favorite position at -3½ -111, according to Caesars. The over/under is set at 47½, with the under slightly favored at u47½ -113.

For those looking to place smart bets, understanding how these odds have shifted is crucial. Initially, the Buccaneers opened with a tighter spread, suggesting increased confidence in their performance. On the moneyline, Tampa Bay stands at -179, with the 49ers at +145, offering potential value for those backing the visitors. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

For a comprehensive look at the latest odds, visit our NFL odds page. The insights provided can guide you in making informed decisions, ensuring you capitalize on any shifts in betting lines and odds. Whether you're a seasoned bettor or new to the game, these details are pivotal in maximizing your returns. Don't miss out on this NFL showdown and the chance to make your mark in the betting world!