Oct 12, 2025 4:25 PM EDT

Week 6

San Francisco

4-1

Tampa Bay

-3½ (-111)o47½ (-107)

CBS

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San Francisco 49ers vs Tampa Bay Buccaneers Game Props

Updated:Oct 11, 2025 2:33 AM EDT

Get ready for an electrifying showdown as the San Francisco 49ers take on the Tampa Bay Buccaneers on October 12, 2025, at Raymond James Stadium in Tampa, FL. This Sunday night football clash promises to be a thrilling encounter, with both teams bringing their A-game to the field. The 49ers, known for their robust pass offense, will face off against the Buccaneers' formidable pass defense. On the other hand, Tampa Bay's run offense will be tested against San Francisco's stout run defense.

Our game projections suggest a close match, with touchdowns and field goals likely to play a crucial role. Keep an eye on Christian McCaffrey, who has a high hit rate for scoring the first touchdown, making him a prop bet with high EV. The game will be broadcasted on CBS, ensuring you don't miss any of the action.

In recent encounters, our prop bets have shown a high success rate, particularly in markets involving first touchdowns and total points. For those looking to make informed bets, our OddsTrader Turbo subscription offers detailed insights and Start your OddsTrader Turbo subscription.

Whether you're backing the 49ers or the Buccaneers, understanding the dynamics of pass protection versus pass rush will be key. As always, make sure to check out the latest NFL player props for more betting opportunities.

What are the best prop bets for this game?

Total Points Odds/Even

BEST LINE

ODDTotal Points Odds/Even

EVENTotal Points Odds/Even

Total Points Odds/Even (1st Half)

BEST LINE

ODDTotal Points Odds/Even

EVENTotal Points Odds/Even

Total Points Odds/Even (4th Q)

BEST LINE

ODDTotal Points Odds/Even

EVENTotal Points Odds/Even

Both Teams To Score 10+ Points

BEST LINE

YESBoth Teams To Score 10+ Points

NOBoth Teams To Score 10+ Points

Both Teams To Score 20+ Points

BEST LINE

YESBoth Teams To Score 20+ Points

NOBoth Teams To Score 20+ Points

Both Teams To Score 30+ Points

BEST LINE

YESBoth Teams To Score 30+ Points

NOBoth Teams To Score 30+ Points

Will there be a Safety

BEST LINE

YESWill there be a Safety

NOWill there be a Safety

Tampa Bay Team Total

BEST LINE

OVERTampa Bay Team Total

UNDERTampa Bay Team Total

San Francisco Team Total

BEST LINE

OVERSan Francisco Team Total

UNDERSan Francisco Team Total

Tampa Bay Total (First Half)

BEST LINE

OVERTampa Bay Total

UNDERTampa Bay Total

San Francisco Total (First Half)

BEST LINE

OVERSan Francisco Total

UNDERSan Francisco Total

Tampa Bay Total Touchdown

BEST LINE

OVERTampa Bay Total Touchdown

UNDERTampa Bay Total Touchdown

San Francisco Total Touchdown

BEST LINE

OVERSan Francisco Total Touchdown

UNDERSan Francisco Total Touchdown

Will there be Overtime

BEST LINE

YESWill there be Overtime

NOWill there be Overtime

First Team to 10 Points

BEST LINE

San FranciscoFirst Team to 10 Points

Tampa BayFirst Team to 10 Points

NEITHERFirst Team to 10 Points

First Team to 15 Points

BEST LINE

San FranciscoFirst Team to 15 Points

Tampa BayFirst Team to 15 Points

NEITHERFirst Team to 15 Points

First Team to 20 Points

BEST LINE

San FranciscoFirst Team to 20 Points

Tampa BayFirst Team to 20 Points

NEITHERFirst Team to 20 Points

First Team to 25 Points

BEST LINE

San FranciscoFirst Team to 25 Points

Tampa BayFirst Team to 25 Points

NEITHERFirst Team to 25 Points

First Team to 30 Points

BEST LINE

San FranciscoFirst Team to 30 Points

Tampa BayFirst Team to 30 Points

NEITHERFirst Team to 30 Points

First Team to 35 Points

BEST LINE

San FranciscoFirst Team to 35 Points

Tampa BayFirst Team to 35 Points

NEITHERFirst Team to 35 Points

Team to score first field goal

EXPECTED VALUECOVER PROB.EXPECTED VALUEBEST LINE

San FranciscoTeam to score first field goal

-10.5%

Tampa BayTeam to score first field goal

+4.3%

Team to score most touchdowns

BEST LINE

San FranciscoTeam to score most touchdowns

Tampa BayTeam to score most touchdowns

Team to score the first touchdown

EXPECTED VALUECOVER PROB.EXPECTED VALUEBEST LINE

San FranciscoTeam to score the first touchdown

-12.0%

Tampa BayTeam to score the first touchdown

+6.6%

Team to score last

BEST LINE

San FranciscoTeam to score last

Tampa BayTeam to score last

Team to use timeout first

BEST LINE

San FranciscoTeam to use timeout first

Tampa BayTeam to use timeout first

Team to score first

BEST LINE

San FranciscoTeam to score first

Tampa BayTeam to score first

Team to use first challenge

BEST LINE

San FranciscoTeam to use first challenge

Tampa BayTeam to use first challenge

Touchdowns

BEST LINE

OVERTouchdowns

UNDERTouchdowns

NFL

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Carolina 2-3 79% +3 -105FanDuel
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New Orleans 1-4 60% +3½ -110BetMGM
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Las Vegas 1-4 34% -4 -109Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/124:25 PM San Francisco 4-1 62% +3½ -111Caesars
Tampa Bay 4-1 38% -3 -118BetMGM
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Green Bay 2-1-1 31% -14½ -105Bet365
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Kansas City 2-3 33% -2 -113SugarHouse
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