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The San Francisco 49ers are set to face off against the Tampa Bay Buccaneers on October 12, 2025, in a thrilling Sunday night football clash at Raymond James Stadium in Tampa, FL. As NFL Week 6 unfolds, fans can catch the action live on CBS. Our expert picks suggest this game will be a nail-biter with the 49ers showing a slight edge. The 49ers have a predicted score of 22 against the Buccaneers' 24, indicating a close contest. Our betting tips favor the 49ers with a +3 point spread due to their solid recent performance.
In the past 10 games, the 49ers have shown a promising hit rate with a 70% success in 2way bets, making them a reliable choice for bettors. This game also sees a predicted total score under 47.5, which aligns with our American Total market predictions. Our prediction model has been profitable in the last 10 games, winning 6 of them. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. For more insights, check out our NFL picks page.
![]() N.Y. Jets 0-571% +7½ -118BetMGM | |||||||
![]() Pittsburgh 3-139% -5½ -120FanDuel | |||||||
![]() Indianapolis 4-131% -7 -105FanDuel | |||||||
![]() Baltimore 1-466% +7½ -115BetRivers | |||||||
Jacksonville 4-178% +1½ -120FanDuel | |||||||
Carolina 2-379% +3 -105FanDuel | |||||||
Miami 1-465% +4½ -122FanDuel | |||||||
New Orleans 1-460% +3½ -110BetMGM | |||||||
![]() Las Vegas 1-434% -4 -109Caesars | |||||||
![]() Tampa Bay 4-138% -3 -118BetMGM | |||||||
Green Bay 2-1-131% -14½ -105Bet365 | |||||||
![]() Kansas City 2-333% -2 -113SugarHouse | |||||||
![]() Atlanta 2-284% +5 -118BetMGM | |||||||
![]() Washington 3-224% -4½ -108BetRivers | |||||||
![]() N.Y. Giants 2-434 +7½ -105BetMGM |
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