- All
- 1st half
- 2nd half
- 1st quarter
- 2nd quarter
- 3rd quarter
- 4th quarter
Personalize your notifications and get updates on the teams, players or events you care about most.
FINAL
Sep 28, 2025 4:05 PM EDT
JAX 26 vs SF 21
Week 4
SF
-3 (-110)o46 (-114)
FOXBETCAST
PLAYS
MATCHUP
PREDICTION
ODDS
PLAYER PROPS
GAME PROPS
INJURIES
WEATHER
CHAT
Event NotificationsStay on top of the action with alerts for game start, scoring, odds updates, predictions and more.
Don't show me this again
Betting Trends: Jaguars vs 49ers
Updated:Sep 28, 2025 3:22 AM EDT
The much-anticipated clash between the Jacksonville Jaguars and the San Francisco 49ers on September 28, 2025, promises to be a riveting encounter for NFL fans and bettors alike. Held at Levi's Stadium in Santa Clara, CA, the game will be broadcasted on FOX, ensuring fans won't miss a moment of the action. The Jaguars, led by quarterback Trevor Lawrence, will face a formidable opponent in the 49ers, who boast a strong offensive lineup with Brock Purdy at the helm. The betting trends highlight the 49ers as favorites with a point spread of -3.5, according to Caesars. The total points over/under is set at 46.5, making for a strategic betting opportunity.
Jacksonville's recent performance shows a mixed bag of results, with a notable win against the Houston Texans, while the 49ers have maintained a solid winning streak. The Jaguars' pass offense, led by Lawrence, will be put to the test against the 49ers' robust pass defense. Meanwhile, San Francisco's run offense will aim to exploit any weaknesses in Jacksonville's run defense. Injuries could play a pivotal role, with Jacksonville's Dyami Brown listed as questionable, potentially impacting their passing game.
For bettors, the 49ers' home advantage at Levi's Stadium and their recent head-to-head dominance over the Jaguars, including a 34-3 victory in 2023, could sway betting decisions. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
ATS Records
All
12-6 (3rd)Against the Spread12-7 (5th)
13-5 (4th)Straight Up13-6 (8th)
+5.9Straight Up Units+5.5
10-7-1Over / Under12-7
TEAM MATCHUP
OFF
DEF
OFF
DEF
27.9Points25.7
14.9First Half13.3
13Second Half12.4
5.7First Quarter5.6
9.2Second Quarter7.7
6.1Third Quarter5.5
6.4Fourth Quarter6.8
337.4Total Yards351.4
5.6Yards Per Play5.7
222.3Passing Yards244.5
20.2 - 33.1 (61.1%)Completions-Attempts23.4 - 33.8 (69.3%)
6.3Yards Per Passing Play6.9
2.4 (15)Sacks (Yards)1.6 (9)
115.1Rushing Yards106.9
28.8Attempts28.3
4Yards Per Rush3.8
20.91st Downs22.3
11.5Passing13.9
7.3Rushing7
2.1Penalties1.4
5 / 12.8 (39.2%)3rd Down6.2 / 12.5 (49.8%)
1 / 1.7 (58.6%)4th Down0.8 / 1.3 (59.1%)
2.5 / 4 (61.8%)Red Zone2.5 / 3.9 (65.2%)
7.5 (63.5)Penalties (Yards)4.9 (38.3)
1.6Turnovers0.7
1.3Interceptions0.4
0.4Fumbles Lost0.4
64.3Total Plays63.6
5.7Kickoffs5.6
3.4Returns3
93.6Return Yards81.5
27.4Yards Per Return27.2
3.5Punts2.6
1.5Returns1.5
20.9Return Yards17.1
13.7Yards Per Return11.6
Recent Results
Game
Score
ATS
O/U
Game
Score
ATS
O/U
HEAD TO HEAD
ABC/ESPN, ESPN, ABC
NFL
Spread
- Spread
- Money
- Total
- Merged
Game
- Game
- 1H
- 2H
- 1Q
- 2Q
- 3Q
- 4Q
NFLSuper Bowl
Download the app© OddsTrader 2026 All Rights Reserved
The content on this site is for entertainment purposes only. OddsTrader makes no representation or warranty as to the accuracy of the information given or the outcome of any game or event. Please be aware of and respect the laws regarding sports betting for your jurisdiction as they vary from state to state. OddsTrader does not target underaged persons. Using this information to contravene any law or statute is prohibited. This site contains commercial content, and OddsTrader may be compensated for the links provided on this site.Disclosure.
OddsTrader no longer operates under any U.S. license, including Pennsylvania.
Seek help with a gambling addiction at 1-800-Gambler.