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NFL Week 6 Odds: Opening Lines

Isiah Pacheco Kansas City Chiefs NFL player
Isiah Pacheco #10 of the Kansas City Chiefs is tackled by Jonathan Harris #92 of the Denver Broncos during the second quarter at Arrowhead Stadium on January 01, 2023. David Eulitt/Getty Images/AFP

Week 6 of the regular season brings us an action-packed schedule with a total of 15 games to enjoy. Only two teams, the Packers and the Steelers, are on a bye week. The week kicks off on Thursday, October 12, with a thrilling divisional game between the Broncos and the Chiefs at Arrowhead Stadium.

Sunday showcases the third and final game in London. The Ravens and the Titans will kick off at 9:30 AM, providing fans with an early dose of football. It’s worth noting that there are still two games scheduled for Germany in Weeks 9 and 10, adding to the international flavor of the season.

Shifting our focus back to the United States, the 1 PM slate offers intriguing matchups, including the 49ers vs. Browns and the Seahawks vs. Bengals. In the late afternoon slot, the Patriots in Las Vegas and the Eagles vs. the Jets take center stage.

Meanwhile, prime-time games continue to deliver entertainment. Sunday Night Football (SNF) features the Giants visiting Buffalo to face the Bills, providing a showdown between two competitive teams. On Monday Night Football (MNF), the Cowboys travel to Los Angeles to take on the Chargers, creating an electrifying atmosphere in La-La Land.

NFL Week 6 Odds

For a comprehensive view of the complete list of NFL Week 6 odds, refer to the information provided below.

Matchup Date Time Spread Over/Under
49ers vs. Seahawks Thursday, October 10 08:15 PM ET 49ers -5.5 (-120) 47
Jaguars vs. Bears (London) Sunday, October 13 09:30 AM ET Bears PK (-120) 46.5
Buccaneers vs. Saints Sunday, October 13 01:00 PM ET Saints -1 (-110) 42
Cardinals vs. Packers Sunday, October 13 01:00 PM ET Packers -4.5 (-120) 47.5
Colts vs. Titans Sunday, October 13 01:00 PM ET Colts -2 (-120) 45
Browns vs. Eagles Sunday, October 13 01:00 PM ET Eagles -3 (-120) 46.5
Texans vs. Patriots Sunday, October 13 01:00 PM ET Texans -4.5 (-120) 42.5
Commanders vs. Ravens Sunday, October 13 01:00 PM ET Ravens -8.5 (-120) 41.5
Chargers vs. Broncos Sunday, October 13 01:00 PM ET Chargers -2.5 (-120) 42.5
Steelers vs. Raiders Sunday, October 13 04:05 PM ET Raiders PK (-120) 44.5
Falcons vs. Panthers Sunday, October 13 04:05 PM ET Falcons -3 (-120) 42.5
Lions vs. Cowboys Sunday, October 13 04:25 PM ET Cowboys -1 (-120) 50.5
Bengals vs. Giants Sunday, October 13 04:25 PM ET Bengals -5.5 (-120) 44
Bills vs. Jets Sunday, October 13 08:20 PM ET Jets -1.5 (-120) 46.5

*Opening odds via Caesars Sportsbook (check our Caesars Sportsbook Review)

Best NFL Week 6 Spread Available

Matchup Current Best Spread Available
49ers vs. Seahawks 49ers -5.5 (-120) at Caesars Sportsbook
Jaguars vs. Bears (London) Jaguars -1 (-110) at Bet365
Buccaneers vs. Saints Saints -1 (-110) at Caesars Sportsbook
Cardinals vs. Packers Packers -4.5 (-120) at Caesars Sportsbook
Colts vs. Titans Colts -2 (-120) at Caesars Sportsbook
Browns vs. Eagles Eagles -3 (-120) at Caesars Sportsbook
Texans vs. Patriots Texans -4.5 (-120) at Caesars Sportsbook
Commanders vs. Ravens Ravens -8.5 (-120) at Caesars Sportsbook
Chargers vs. Broncos Chargers -2.5 (-120) at Caesars Sportsbook
Steelers vs. Raiders Raiders PK (-120) at Caesars Sportsbook
Falcons vs. Panthers Falcons -3 (-120) at Caesars Sportsbook
Lions vs. Cowboys Cowboys -1 (-120) at Caesars Sportsbook
Bengals vs. Giants Bengals -5.5 (-120) at Caesars Sportsbook
Bills vs. Jets Jets -1.5 (-120) at Caesars Sportsbook

More Weekly NFL Odds Previews

Eager to explore the upcoming NFL schedule for the most recent odds or curious about the odds of a game that has already taken place? Check out our odds preview covering all 18 weeks of the NFL regular season!

*21+ Seek help with a gambling addiction at 1-800-Gambler

*The line and/or odds referenced in this article might have changed since the content was published. For the latest information on line movements, visit OddsTrader’s free betting odds tool.

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