The offseason drama is over for Baker Mayfield, who is finally out of Cleveland! There’s some drama left though as Mayfield was traded to the Panthers, who play the Browns in Week 1. Will Mayfield get some payback? The Mayfield trade moved this line — below you can check out the latest odds for this Week 1 clash and all the other contests.
The start of the 2022 NFL season is less than six weeks away and we have a full slate of games to look forward to. Week 1 starts with the Bills visiting the defending champion Rams in a potential Super Bowl LVII preview.
Other can’t-miss games include the Cowboys hosting Tom Brady and the Buccaneers on Sunday Night Football and some awkward reunions when Baker Mayfield faces the Browns and Russell Wilson visits the Seahawks.
Here is the full slate of games and the latest NFL Week 1 odds.
NFL Week 1 Odds
The NFL odds for Week 1 are headlined by Mayfield hosting the Browns and Wilson’s return to Seattle — as a member of the Broncos.
| Matchup | Time | Spread | Over/Under |
|---|---|---|---|
| Bills vs. Rams | Thursday, September 8 – 08:20 PM EST at SoFi Stadium | Rams PK | 52 |
| Saints vs. Falcons | Sunday, September 11, 2022 – 01:00 PM EST at Mercedes-Benz Stadium | Saints -5 | 41.5 |
| Browns vs. Panthers | Sunday, September 11, 2022 – 01:00 PM EST at Bank of America Stadium | Browns -1 | 42 |
| 49ers vs. Bears | Sunday, September 11, 2022 – 01:00 PM EST at Soldier Field | 49ers -6.5 | 42 |
| Steelers vs. Bengals | Sunday, September 11, 2022 – 01:00 PM EST at Paul Brown Stadium | Bengals -6.5 | 44.5 |
| Eagles vs. Lions | Sunday, September 11, 2022 – 01:00 PM EST at Ford Field | Eagles -4 | 46.5 |
| Colts vs. Texans | Sunday, September 11, 2022 – 01:00 PM EST at NRG Stadium | Colts -8 | 44 |
| Patriots vs. Dolphins | Sunday, September 11, 2022 – 01:00 PM EST at Hard Rock Stadium | Dolphins -2.5 | 44.5 |
| Ravens vs. Jets | Sunday, September 11, 2022 – 01:00 PM EST at MetLife Stadium | Ravens -6 | 45 |
| Jaguars vs. Commanders | Sunday, September 11, 2022 – 01:00 PM EST at FedExField | Commanders -4 | 44 |
| Chiefs vs. Cardinals | Sunday, September 11, 2022 – 04:25 PM EST at State Farm Stadium | Chiefs -3 | 53 |
| Raiders vs. Chargers | Sunday, September 11, 2022 – 04:25 PM EST at SoFi Stadium | Chargers -3.5 | 52 |
| Packers vs. Vikings | Sunday, September 11, 2022 – 04:25 PM EST at U.S. Bank Stadium | Packers -2 | 49 |
| Giants vs. Titans | Sunday, September 11, 2022 – 04:25 PM EST at Nissan Stadium | Titans -6.5 | 44 |
| Buccaneers vs. Cowboys | Sunday, September 11, 2022 – 08:20 PM EST at AT&T Stadium | Buccaneers -2 | 52 |
| Broncos vs. Seahawks | Monday, September 12, 2022 – 08:15 PM EST at Lumen Field | Broncos -5 | 41.5 |
| Matchup | Best Spread Available |
|---|---|
| Bills vs. Rams | Bills +1 at Bet365 |
| Saints vs. Falcons | Ravens -5.5 at BetMGM |
| Browns vs. Panthers | Browns -0.5 at SBK |
| 49ers vs. Bears | 49ers -5.5 at MaximBet |
| Steelers vs. Bengals | Bengals -6.5 at PointsBet |
| Eagles vs. Lions | Eagles -3.5 at SBK |
| Colts vs. Texans | Colts -7.5 at BetMGM |
| Patriots vs. Dolphins | Dolphins -2.5 at Caesars Sportsbook |
| Ravens vs. Jets | Ravens -5.5 at BetMGM |
| Jaguars vs. Commanders | Commanders -3.5 at BetMGM |
| Chiefs vs. Cardinals | Chiefs -2.5 at Unibet |
| Raiders vs. Chargers | Raiders -3.5 at Caesars |
| Packers vs. Vikings | Packers -2 at Caesars Sportsbook |
| Giants vs. Titans | Giants -2.5 at SBK |
| Buccaneers vs. Cowboys | Buccaneers -2 at Caesars Sportsbook |
| Broncos vs. Seahawks | Broncos -4.5 at MaximBet |
