NFL Week 1 Odds: Latest NFL Spreads, Totals, Moneylines, etc.

Baker Mayfield of the Carolina Panthers. Jacob Kupferman/Getty Images/AFP

The offseason drama is over for Baker Mayfield, who is finally out of Cleveland! There’s some drama left though as Mayfield was traded to the Panthers, who play the Browns in Week 1. Will Mayfield get some payback? The Mayfield trade moved this line — below you can check out the latest odds for this Week 1 clash and all the other contests.

The start of the 2022 NFL season is less than six weeks away and we have a full slate of games to look forward to. Week 1 starts with the Bills visiting the defending champion Rams in a potential Super Bowl LVII preview. 

Other can’t-miss games include the Cowboys hosting Tom Brady and the Buccaneers on Sunday Night Football and some awkward reunions when Baker Mayfield faces the Browns and Russell Wilson visits the Seahawks.

Here is the full slate of games and the latest NFL Week 1 odds

NFL Week 1 Odds

The NFL odds for Week 1 are headlined by Mayfield hosting the Browns and Wilson’s return to Seattle — as a member of the Broncos.

Bills vs. RamsThursday, September 8 – 08:20 PM EST at SoFi StadiumRams PK52
Saints vs. FalconsSunday, September 11, 2022 – 01:00 PM EST at Mercedes-Benz StadiumSaints -541.5
Browns vs. PanthersSunday, September 11, 2022 – 01:00 PM EST at Bank of America StadiumBrowns -142
49ers vs. BearsSunday, September 11, 2022 – 01:00 PM EST at Soldier Field49ers -6.542
Steelers vs. BengalsSunday, September 11, 2022 – 01:00 PM EST at Paul Brown StadiumBengals -6.544.5
Eagles vs. LionsSunday, September 11, 2022 – 01:00 PM EST at Ford Field    Eagles -446.5
Colts vs. TexansSunday, September 11, 2022 – 01:00 PM EST at NRG StadiumColts -844
Patriots vs. DolphinsSunday, September 11, 2022 – 01:00 PM EST at Hard Rock StadiumDolphins -2.544.5
Ravens vs. JetsSunday, September 11, 2022 – 01:00 PM EST at MetLife Stadium      Ravens -645
Jaguars vs. CommandersSunday, September 11, 2022 – 01:00 PM EST at FedExField   Commanders -444
Chiefs vs. CardinalsSunday, September 11, 2022 – 04:25 PM EST at State Farm StadiumChiefs -353
Raiders vs. ChargersSunday, September 11, 2022 – 04:25 PM EST at SoFi StadiumChargers -3.552
Packers vs. VikingsSunday, September 11, 2022 – 04:25 PM EST at U.S. Bank Stadium   Packers -249
Giants vs. TitansSunday, September 11, 2022 – 04:25 PM EST at Nissan StadiumTitans -6.544
Buccaneers vs. CowboysSunday, September 11, 2022 – 08:20 PM EST at AT&T StadiumBuccaneers -2 52
Broncos vs. SeahawksMonday, September 12, 2022 – 08:15 PM EST at Lumen FieldBroncos -541.5
Odds courtesy of Caesars Sportsbook as of July 22

MatchupBest Spread Available
Bills vs. RamsBills +1 at Bet365
Saints vs. FalconsRavens -5.5 at BetMGM 
Browns vs. Panthers Browns -0.5 at SBK 
49ers vs. Bears 49ers -5.5 at MaximBet 
Steelers vs. Bengals Bengals -6.5 at PointsBet 
Eagles vs. Lions Eagles -3.5 at SBK 
Colts vs. Texans Colts -7.5 at BetMGM 
Patriots vs. Dolphins Dolphins -2.5 at Caesars Sportsbook 
Ravens vs. Jets Ravens -5.5 at BetMGM 
Jaguars vs. Commanders Commanders -3.5 at BetMGM 
Chiefs vs. Cardinals Chiefs -2.5 at Unibet 
Raiders vs. Chargers Raiders -3.5 at Caesars 
Packers vs. Vikings Packers -2 at Caesars Sportsbook
Giants vs. Titans Giants -2.5 at SBK 
Buccaneers vs. Cowboys Buccaneers -2 at Caesars Sportsbook 
Broncos vs. SeahawksBroncos -4.5 at MaximBet 
Odds as of July 22 

More Weekly NFL Odds Previews

Week 2 odds

Week 3 odds

Week 4 odds

Week 5 odds

Week 6 odds

Week 7 odds

Week 8 odds

Week 9 odds

Week 10 odds

Week 11 odds

Week 12 odds

Week 13 odds

Week 14 odds

Week 15 odds

Week 16 odds

Week 17 odds

Week 18 odds is your sports betting command center. Read featured betting strategy compiled from a panel of leading sports betting experts.

Site Footer