NFL Week 4 Odds: One More Mahomes-Brady Clash

Quarterback Patrick Mahomes #15 of the Kansas City Chiefs. David Eulitt/Getty Images/AFP

NFL Week 4 will treat us to some incredible football games to bet on, including the Chiefs visiting the Buccaneers in another chapter of the Mahomes-Brady rivalry. Below you can check out the latest odds for all Week 4 clashes.

Week 4 has many games with betting potential, including the Bills visiting the Ravens and the Broncos-Raiders battle in Las Vegas. 

Here is the full slate of games and the latest NFL Week 4 odds

NFL Week 4 Odds

These are the NFL odds for Week 4, headlined by Tom Brady and the Buccaneers opening as 3-point home favorites against Patrick Mahomes and the Chiefs on Sunday Night Football.

MatchupTimeSpreadOver/Under
Steelers vs. BrownsThursday, September 29, 2022 – 08:15 PM EST at Paul Brown StadiumBrowns -3.5N/A
Saints vs. PanthersSunday, October 2, 2022 – 09:30 AM EST at Tottenham Hotspur StadiumSaints -1.5N/A
Texans vs. Bears   Sunday, October 2, 2022 – 01:00 PM EST at Mercedes-Benz StadiumBears -3.5N/A
Chiefs vs. Colts    Sunday, October 2, 2022 – 01:00 PM EST at M&T Bank StadiumChiefs -2.5N/A
Bills vs. Dolphins  Sunday, October 2, 2022 – 01:00 PM EST at AT&T StadiumBills -4N/A
Lions vs. VikingsSunday, October 2, 2022 – 01:00 PM EST at Ford FieldVikings -6.5N/A
Ravens vs. PatriotsSunday, October 2, 2022 – 01:00 PM EST at NRG StadiumPatriots PKN/A
Bengals vs. JetsSunday, October 2, 2022 – 01:00 PM EST at Lucas Oil StadiumBengals -4.5N/A
Raiders vs. TitansSunday, October 2, 2022 – 01:00 PM EST at MetLife StadiumTitans -2.5N/A
Eagles vs. CommandersSunday, October 2, 2022 – 01:00 PM EST at Lincoln Financial FieldEagles -2.5N/A
Jaguars vs. ChargersSunday, October 2, 2022 – 01:00 PM EST at Acrisure StadiumChargers -10N/A
Rams vs. Cardinals           Sunday, October 2, 2022 – 04:05 PM EST at Bank of America StadiumRams -1N/A
Falcons vs. SeahawksSunday, October 2, 2022 – 04:25 PM EST at Lambeau FieldSeahawks -3.5N/A
Packers vs. BuccaneersSunday, October 2, 2022 – 04:25 PM EST at Allegiant StadiumBuccaneers -352
49ers vs. BroncosSunday, October 2, 2022 – 08:20 PM EST at Raymond James StadiumBroncos -346.5 
Cowboys vs. GiantsMonday, October 3, 2022 – 08:15 PM EST at Levi’s StadiumCowboys -348
Odds courtesy of Caesars Sportsbook as of July 22

MatchupBest Spread Available
Dolphins vs. BengalsBengals -4 at Caesars Sportsbook
Vikings vs. SaintsVikings +1 at FanDuel
Browns vs. Falcons           Browns -2.5 at Caesars Sportsbook
Bills vs. Ravens      Bills -1 at DraftKings
Commanders vs. CowboysCowboys -6 at Caesars Sportsbook
Seahawks vs. LionsLions -1 at DraftKings
Chargers vs. TexansChargers -8 at DraftKings
Titans vs. Colts    Colts -3 at Caesars Sportsbook
Bears vs. GiantsGiants -2.5 at DraftKings
Jaguars vs. EaglesEagles -6.5 at DraftKings
Jets vs. SteelersSteelers -3.5 at DraftKings
Cardinals vs. PanthersCardinals -1.5 at DraftKings
Patriots vs. PackersPackers -5 at DraftKings
Broncos vs. RaidersRaiders PK at Caesars Sportsbook
Chiefs vs. BuccaneersBuccaneers -2.5 at Unibet
Rams vs. 49ersRams PK at Caesars Sportsbook
Odds as of July 22 

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