- Spread
- Money
- Total
- Merged
Personalize your notifications and get updates on the teams, players or events you care about most.
Nov 16, 2025 4:05 PM EST
Week 11
SF
-3 (-105)o48 (-118)
FOXMATCHUP
PREDICTION
ODDS
BOOSTS
PLAYER PROPS
GAME PROPS
INJURIES
WEATHER
CHAT
Event NotificationsStay on top of the action with alerts for game start, scoring, odds updates, predictions and more.
Don't show me this again
Arizona Cardinals vs San Francisco 49ers Picks
Updated:Nov 13, 2025 1:42 AM EST
The upcoming NFL showdown on November 16, 2025, features the Arizona Cardinals taking on the San Francisco 49ers at State Farm Stadium in Glendale, AZ. This Sunday football game promises to be an exciting matchup, broadcast live on FOX. Our expert picks have the 49ers favored to win with a predicted score of 26 to 21, covering a -2.5 point spread. The total points are expected to stay under 49, with a predicted total score of approximately 46.5.
Our prediction model has been profitable in recent games, especially on the point spread market, boasting a strong hit rate and positive expected value (EV). For example, the model shows a 54.7% coverage on the 49ers -2.5 spread with a slight positive EV, indicating bettors have an edge by backing San Francisco. This insight can help bettors make smart decisions ahead of this nail-biting contest.
For more detailed NFL picks and expert predictions, visit our comprehensive NFL picks page. Ready to bet smarter? Start your OddsTrader Turbo subscription or place your bet with a U.S. regulated sportsbook and profit off the edge.
UPCOMING GAME PREDICTION
Spread
Money
Total
SFSpread
CONSENSUS LINE
-3 (-108)
PROJECTION
SF (26) - ARI (21)
COVER PROBABILITY
EXPECTED VALUE
+3.0%
BET RATING
SEASON COVER %
5/10
50%
OTHER BETS
Sun 11/16 4:05 PMSF @ ARI
World
- World
- New Jersey
- New York
- Pennsylvania
- Indiana
- Colorado
- Iowa
- Illinois
- Virginia
- West Virginia
- Tennessee
- Connecticut
- Michigan
- Arizona
- Louisiana
- Wyoming
- Kansas
- Washington DC
- Maryland
- Ohio
- Massachusetts
- Mississippi
View Sportsbooks, Odds and Promotions available in your state.
NFL
Spread
Game
- Game
- 1H
- 2H
- 1Q
- 2Q
- 3Q
- 4Q
This Week
Last Week
NFLWeek 11
 New England 8-225% -12½ -118FanDuel | |||||||
 Miami 3-767% -2½ -115Bet365 | |||||||
 N.Y. Giants 2-864% +7 -104FanDuel | |||||||
 Buffalo 6-359% -5½ -110Bet365 | |||||||
 Pittsburgh 5-465% -5½ -110Bet365 | |||||||
 Tennessee 1-878% +7 -117SugarHouse | |||||||
 Minnesota 4-529% -2½ -115Caesars | |||||||
 Atlanta 3-620% -3½ -105Bet365 | |||||||
 Jacksonville 5-446% +3 -114BetRivers | |||||||
 L.A. Rams 7-254% -3 -109BetRivers | |||||||
 Arizona 3-675% +3 -102Caesars | |||||||
 Cleveland 2-785% +8 -117SugarHouse | |||||||
 Denver 8-270% +4 -114BetRivers | |||||||
 Philadelphia 7-273% -2½ -114FanDuel | |||||||
 Las Vegas 2-791% +3½ -114Caesars |
Download the app© OddsTrader 2025 All Rights Reserved
The content on this site is for entertainment purposes only. OddsTrader makes no representation or warranty as to the accuracy of the information given or the outcome of any game or event. Please be aware of and respect the laws regarding sports betting for your jurisdiction as they vary from state to state. OddsTrader does not target underaged persons. Using this information to contravene any law or statute is prohibited. This site contains commercial content, and OddsTrader may be compensated for the links provided on this site.Disclosure.
OddsTrader is licensed to operate in NJ, NY, PA, IN, CO, IA, IL, VA, WV, TN, CT, MI, AZ, LA, WY, OR, KS, DC, MA & OH.
Seek help with a gambling addiction at 1-800-Gambler.
OddsTrader uses cookies to help us provide, protect & improve our services. See ourPrivacy Policyfor more details.
ACCEPT & CLOSE