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Nov 30, 2025 1:00 PM EST
Week 13
SF
-5½ (-113)o35½ (-109)
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Betting Trends San Francisco 49ers vs Cleveland Browns
Updated:Nov 30, 2025 1:11 AM EST
The upcoming Sunday football matchup on November 30, 2025, features the San Francisco 49ers vs Cleveland Browns at Huntington Bank Field in Cleveland, OH. This NFL Week 13 game will be broadcast on CBS, offering prime betting opportunities for fans and bettors alike.
Starting quarterbacks Brock Purdy for the 49ers and Shedeur Sanders for the Browns bring an intriguing dynamic. Purdy leads a strong San Francisco passing offense averaging 249.4 yards per game against a Cleveland defense allowing 170.7 passing yards. Meanwhile, Cleveland's offense, led by Sanders, averages 163.5 passing yards against a San Francisco defense that allows 241.8 passing yards, suggesting the 49ers might exploit the Browns' secondary.
In the run game, the Browns average 102.3 rushing yards while the 49ers allow about 100.9 rushing yards per game. Both teams have solid run defenses and effective rushing attacks, which could lead to a balanced ground game. Pass protection favors San Francisco with fewer sacks allowed compared to Cleveland, while San Francisco's pass rush is somewhat limited, giving Browns some opportunities to pressure Purdy.
Injuries could impact this game, with key Browns players like Alex Wright and Adin Huntington ruled out, and Jerome Ford questionable but likely to play. The 49ers are missing star linebacker Fred Warner and defensive lineman Nick Bosa, which could weaken their defense.
The betting trends favor the 49ers as 5.5-point favorites with a total points line set at 35.5. The Browns have a 4-1 ATS home record, while the 49ers boast a 5-2 ATS away record, indicating both teams perform well against the spread in their respective environments. This matchup's relatively low total suggests a game leaning toward a defensive battle, so betting the under might be wise.
Recent performances show the Browns coming off a solid 24-10 win over the Raiders, while the 49ers recently won 20-9 against the Panthers. For bettors seeking detailed betting insights and trends, this game offers a wealth of data to analyze. The previous close encounter on October 15, 2023, saw the Browns edge the 49ers 19-17, adding extra intrigue to this rematch.
Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
Check out the last matchup on October 15, 2023, where the Browns won 19-17 for more context.
ATS Records
All
7-5 (6th)Against the Spread5-6 (19th)
8-4 (9th)Straight Up3-8 (26th)
+4.0Straight Up Units-2.3
8-4Over / Under6-5
TEAM MATCHUP
OFF
DEF
OFF
DEF
23.4Points16.9
12First Half9.5
11.4Second Half7.5
4.4First Quarter4.4
7.6Second Quarter5.1
4.6Third Quarter3
6.6Fourth Quarter4.5
348.6Total Yards258.5
5.5Yards Per Play4.5
249.4Passing Yards163.5
24.3 - 35 (69.3%)Completions-Attempts19.7 - 34.5 (57.1%)
6.8Yards Per Passing Play4.4
1.6 (11)Sacks (Yards)2.7 (19)
99.2Rushing Yards94.9
27.8Attempts24.9
3.6Yards Per Rush3.8
21.91st Downs16.2
13.6Passing7.8
6.9Rushing6
1.4Penalties2.4
5.8 / 12.6 (46.4%)3rd Down4.5 / 14.3 (31.2%)
0.8 / 1.4 (58.8%)4th Down1 / 1.9 (52.4%)
2.3 / 3.6 (62.8%)Red Zone1.4 / 2.5 (53.6%)
5.3 (40.7)Penalties (Yards)6.9 (55.9)
0.8Turnovers1.1
0.4Interceptions0.8
0.4Fumbles Lost0.3
64.3Total Plays62.2
5.4Kickoffs4.1
3Returns4.2
84.4Return Yards100.9
28.1Yards Per Return24.1
2.8Punts5.8
1.5Returns1.9
15.4Return Yards18.5
10.3Yards Per Return9.7
Priority Injuries
No priority injuries for this team
No priority injuries for this team
Recent Results
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NFLWeek 13
 Indianapolis 8-348% -3 -110Caesars | |||||||
 Tampa Bay 6-526% -3½ -110BetMGM | |||||||
 Tennessee 1-1064% +6½ -120FanDuel | |||||||
 Carolina 6-667% +10½ -110Caesars | |||||||
 Miami 4-724% -5 -115Bet365 | |||||||
 N.Y. Jets 2-973% +3 -105Bet365 | |||||||
 Cleveland 3-842% +5½ -105Caesars | |||||||
 Seattle 8-343% -10½ -105FanDuel | |||||||
 Pittsburgh 6-571% +3 -105Bet365 | |||||||
 L.A. Chargers 7-418% -9 -114SugarHouse | |||||||
 Washington 3-853% +6½ -105Bet365 | |||||||
 New England 10-223% -7 -109Caesars | |||||||
 Detroit 7-524 -3 -105BetMGM | |||||||
 Dallas 6-5-131 +3½ -110BetMGM | |||||||
 Baltimore 6-614 -7½ -114BetRivers | |||||||
 Philadelphia 8-415 -7 -110BetMGM |
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