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NFL Week 12 Odds: Opening Lines

Stefon Diggs Buffalo Bills NFL Thanksgiving
Stefon Diggs 14 of the Buffalo Bills celebrates on the field by eating a turkey leg after defeating the Detroit Lions at Ford Field on November 24 2022 in Detroit Michigan Rey Del RioGetty ImagesAFP

Thanksgiving has finally arrived, bringing with it a cornucopia of football action to savor throughout the day.

What makes it even more delightful is that all three games on the schedule are enticing divisional matchups.

The festivities kick off on Thursday, November 23, with the Green Bay Packers journey to Motown to take on the Lions—a matchup steeped in Thanksgiving tradition.

The excitement doesn’t stop there, as another intense rivalry unfolds when the Commanders visit the Cowboys in Dallas, Texas, a game that carries significant playoff implications for the fiercely competitive NFC East. And let’s not overlook the showdown between the 49ers and the Seahawks, as they lock horns in Seattle.

If you thought we were skipping ahead to Sunday, think again. The 2023 NFL regular season has something special in store—a first-ever Black Friday game. Get ready for the Dolphins and the Jets to square off in New York at 2 PM, adding an extra dose of football excitement to the holiday weekend.

While Sunday’s slate may be slightly trimmed due to the holiday, fear not, as it still delivers a lineup of high-profile matchups. Brace yourself for five divisional clashes throughout the day. In the early afternoon, the Steelers and the Bengals engage in an intense battle in Cincinnati, while the Saints and Falcons engage in their fierce divisional showdown in Atlanta.

As the late afternoon window opens, fans are treated to a delectable choice of two more divisional matchups featuring teams from both the AFC and NFC West. And let’s not forget the highly anticipated game of the week, where the Bills and the Eagles collide in Philadelphia, promising a clash of titans.

Sunday Night Football takes us on another exhilarating ride as the Ravens journey to L.A. to face the Chargers, setting the stage for an electrifying contest. And to bring Week 12 to a close, Monday Night Football showcases a divisional battle between the Bears and the Vikings, set in Minnesota.

NFL Week 12 Odds

Below, you can find the complete list of NFL Week 12 odds.

MatchupDateTimeSpreadOver/Under
Packers vs. LionsThursday, November 2312:30 PM ETLions -7.5 (-110)47
Commanders vs. CowboysThursday, November 2304:30 PM ETCowboys -11 (-110)48.5
49ers vs. SeahawksThursday, November 2308:20 PM ET49ers -7 (-110)43
Dolphins vs. JetsFriday, November 2403:00 PM ETDolphins -9.5 (-110)46.5
Jaguars vs. TexansSunday, November 2601:00 PM ETJaguars -1 (-110)48
Steelers vs. BengalsSunday, November 2601:00 PM ETSteelers -1 (-110)34.5
Panthers vs. TitansSunday, November 2601:00 PM ETTitans -3.5 (-110)37
Saints vs. FalconsSunday, November 2601:00 PM ETSaints PK (-110)42
Buccaneers vs. ColtsSunday, November 2601:00 PM ETColts -2.5 (-110)43.5
Patriots vs. GiantsSunday, November 2601:00 PM ETPatriots -3 (-120)33.5
Browns vs. BroncosSunday, November 2601:00 PM ETBroncos -2.5 (-110)36
Rams vs. CardinalsSunday, November 2604:05 PM ETRams -1 (-110)44.5
Bills vs. EaglesSunday, November 2604:25 PM ETEagles -3.5 (-105)47.5
Chiefs vs. RaidersSunday, November 2604:25 PM ETChiefs -9.5 (-110)44
Ravens vs. ChargersSunday, November 2608:20 PM ETRavens -4 (-110)46.5
Bears vs. VikingsMonday, November 2708:15 PM ETVikings -3.5 (-110)45.5

*Odds via Caesars Sportsbook (check our Caesars Sportsbook Review) as of November 20, 2023.


Best NFL Week 12 Spread Available

MatchupCurrent Best Spread Available
Packers vs. LionsLions -7.5 (-109) at BetRivers
Commanders vs. CowboysCowboys -11 (-110) at Caesars Sportsbook
49ers vs. Seahawks49ers -7 (-109) at BetRivers
Dolphins vs. JetsDolphins -9.5 (-110) at Caesars Sportsbook
Jaguars vs. TexansJaguars -1 (-108) at BetRivers
Steelers vs. BengalsSteelers -1 (-110) at Caesars Sportsbook
Panthers vs. TitansTitans -3.5 (-110) at Caesars Sportsbook
Saints vs. FalconsSaints PK (-110) at Caesars Sportsbook
Buccaneers vs. ColtsColts -2 (-110) at Bet365
Patriots vs. GiantsPatriots -3 (-120) at Caesars Sportsbook
Browns vs. BroncosBroncos -2.5 (-110) at Caesars Sportsbook
Rams vs. CardinalsRams -1 (-107) at BetRivers
Bills vs. EaglesEagles -3.5 (-105) at Caesars Sportsbook
Chiefs vs. RaidersChiefs -9.5 (-110) at Caesars Sportsbook
Ravens vs. ChargersRavens -4 (-110) at Caesars Sportsbook
Bears vs. VikingsVikings -3.5 (-108) at BetRivers

More Weekly NFL Odds Previews

Eager to explore the upcoming NFL schedule for the most recent odds or curious about the odds of a game that has already taken place? Check out our odds preview covering all 18 weeks of the NFL regular season!


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