49ers vs Buccaneers: Betting Trends & Insights

The San Francisco 49ers will face off against the Tampa Bay Buccaneers on October 12, 2025, at Raymond James Stadium in Tampa, FL. This NFL showdown promises to be a thrilling encounter, with both teams looking to gain an edge in the regular season. The 49ers, coming off a recent win against the Rams, have shown resilience, particularly with their strong pass offense led by quarterback Brock Purdy, who is questionable but likely to play. However, San Francisco's defense, particularly against the run, will be tested by the Buccaneers' rushing attack featuring Rachaad White.

Meanwhile, the Buccaneers, led by quarterback Baker Mayfield, will aim to exploit the 49ers' pass defense, which has shown vulnerability in previous matchups. Tampa Bay's defense will also have its hands full containing San Francisco's dynamic offensive weapons, including Christian McCaffrey. The point spread is set at Tampa Bay -3, with total points at 47.5, suggesting a closely contested game.

For bettors, the key lies in the betting trends and game insights. San Francisco's recent performance against the spread (ATS) has been solid, particularly on the road, as seen on our NFL standings page. Tampa Bay's home performance has been less reliable, which could influence betting decisions. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook to maximize your winnings. Catch the action live on CBS.

The 49ers and Buccaneers last met on November 10, 2024, where the 49ers edged out a 23-20 victory, a game you can revisit here. With both teams eager to improve their records, this clash is set to be a highlight of the NFL season.