49ers Vs Buccaneers: Betting Trends

As we gear up for the much-anticipated clash on October 12, 2025, between the San Francisco 49ers and the Tampa Bay Buccaneers, football fans and bettors alike are in for a treat. Taking place at the Raymond James Stadium in Tampa, Florida, this game is set to be a thrilling encounter, broadcasted live on CBS. With the San Francisco 49ers boasting a 4-1 record, they are a formidable force, especially when playing away from home. Their offensive strategy, spearheaded by running back Christian McCaffrey, has been effective, averaging 27.8 rushing attempts per game. On the defensive side, the 49ers are equally strong, with a solid pass defense that has limited opponents to 207.6 passing yards per game. However, they face a challenge with quarterback Brock Purdy ruled out due to a toe injury, leaving room for backup Mac Jones, who is questionable but expected to start.

On the other hand, the Tampa Bay Buccaneers, also at 4-1, have shown resilience at home. Their pass offense, led by quarterback Baker Mayfield, averages 243.4 passing yards per game, but they will miss the contributions of wide receiver Mike Evans, who is out with a hamstring injury. The Buccaneers' defense, known for its strong pass rush, could exploit San Francisco's weakened pass protection.

For bettors, the spread is set at -3.5 in favor of the Buccaneers, with odds available at Caesars. With both teams having a strong season, this game promises to be closely contested. The over/under is set at 47.5, indicating a potentially high-scoring game. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

In their last matchup on November 10, 2024, the 49ers edged out the Buccaneers 23-20. Both teams have strong records, as shown on our NFL standings page. With Sunday night football vibes, this is one game you won't want to miss.